Anti-Plasmodium Compositions And Methods Of Use (1)

Type
Compound(s)

Compositions that inhibit the binding of Plasmodium falciparum to erythrocytes include a family of erythrocyte binding proteins EBPs. The EBPs are paralogues of the P. falciparum binding protein EBA-175. The present invention includes peptides of the paralogues that prevent the binding of P. falciparum. Antibodies specific for each paralogue that also prevent the binding of P. falciparum are included. Methods of the invention utilize the paralogues, antibodies thereof and peptide compositions for the diagnosis, prevention, and treatment of P. falciparum diseases such as malaria, as well as methods for the detection of P. falciparum in biological samples and culture media.

Disease
Malaria
Research areas
Basic research
Vaccine
Condition of use

n/a

IP information

Granted Patent Reference Number(s): US 7,303,751
Abandoned Patent Reference Number(s): PCT/US01/24725; US 60/223,525; US 09/924,154