A NIPD researcher sequenced the K13 gene of a set of malaria parasites obtained from Senegalese malaria patients by a University Cheikh Anta Diop of Dakar researcher. The sequences obtained informed the researchers of the mutations occurring in that gene and the likelihood of the development of artemisinin resistance.
Dr. Hu developed a dipstick diagnostic for S. japonicum, a species of the parasitic flatworm commonly found in the Far East. BVGH connected Dr. Hu with Dr. Alexander Odaibo at the University of Ibadan, who used samples from Schistosoma-infected patients to assess the dipstick’s ability to detect S. mansoni and S. haematobium, the prevailing species in Africa.
A National Institute of Parasitic Diseases, China CDC (NIPD) researcher will sequence the K13 gene of Plasmodium falciparum parasites found within malaria patient blood samples obtained by researchers at the Centre Pasteur du Cameroun (CPC). The researchers seek to assess the development of artemisinin resistance in Plasmodium parasites circulating in Cameroon, and to compare parasite genotypes with the patients’ responses to treatment – specifically parasite clearance.
A University of Ibadan researcher collaborated with an NIPD researcher to work on serum samples from Nigerian schistosomiasis patients. The NIPD researcher hosted a post-doctoral scientist from Nigeria to identify potential Schistosoma mansoni and S. haematobium antigens to incorporate into a schistosomiasis rapid diagnostic.
Dr. Chen developed a PCR assay to identify resistance-causing mutations in Plasmodium parasite genes. Dr. Oyibo was interested in identifying specific mutations in Plasmodium parasites known to cause drug resistance in Nigerian patients, information that could potentially inform antimalarial treatment policy. With funding from NIPD, a graduate student from Dr. Oyibo’s laboratory spent two months at NIPD training on the PCR assay with samples collected from malaria patients in Nigeria. Using Dr. Chen’s assay, the student screened the samples for P. falciparum mutations conferring resistance to drugs.