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The Center for World Health and Medicine (CWHM) at Saint Louis University, USA is a not-for-profit research center dedicated to the discovery and development of medicines to treat diseases that predominantly affect the world’s poor and under-served patient populations. The CWHM consists of a multidisciplinary team of former pharmaceutical company scientists possessing the necessary skill sets required for small molecule drug discovery. The CWHM in partnership with our MCG colleagues at the University of Missouri, St. Louis, USA have state of the art chemistry facilities. We are an accomplished medicinal chemistry group with significant expertise in the design of compounds with the appropriate safety, pharmacokinetic and pharmaceutical properties required for human development. CWHM/MCG chemists also have considerable expertise in structure-based drug design (SBDD) and have collaborations in place with molecular modelers to further enhance our capabilities. The CWHM will consider collaborative proposals to consult or collaborate on neglected disease targets using our medicinal chemistry design and synthetic skill sets.

The Center for World Health and Medicine (CWHM) at Saint Louis University, USA is a not-for-profit research center dedicated to the discovery and development of medicines to treat diseases that predominantly affect the world’s poor and underserved patient populations. The CWHM consists of a multidisciplinary team of former pharmaceutical company scientists possessing the necessary skill sets required for small molecule drug discovery. The CWHM will consider collaborative proposals to develop and optimize target-based or phenotypic assays to identify compounds as useful probes for neglected disease programs. Partners may request screening of available compound collections or provide their own. Lead optimization resources are also available.

The Center for World Health and Medicine (CWHM) at Saint Louis University, USA is a not-for-profit research center dedicated to the discovery and development of medicines to treat diseases that predominantly affect the world’s poor and underserved patient populations. The CWHM consists of a multidisciplinary team of former pharmaceutical company scientists possessing the necessary skill sets required for small molecule drug discovery. The CWHM will consider collaborative proposals to evaluate the pharmacokinetic properties of tool or candidate compounds. Our center possesses the necessary equipment and expertise to conduct in life studies in rodents and complete bioanalytical analyses of samples using LC/MS/MS. We can also conduct in vitro metabolism and protein binding and stability studies.

The Center for World Health and Medicine (CWHM) at Saint Louis University, USA is a not-for-profit research center dedicated to the discovery and development of medicines to treat diseases that predominantly affect the world’s poor and underserved patient populations. The CWHM consists of a multidisciplinary team of former pharmaceutical company scientists possessing the necessary skill sets required for small molecule drug discovery. The CWHM at Saint Louis University will consider requests to evaluate tool compounds and drug candidates for effects on Plasmodium parasite growth in human erythrocytes in vitro. Potential for drug resistance and synergy with standard treatment agents can also be explored.

The Center for World Health and Medicine (CWHM) at Saint Louis University is a not-for-profit research center dedicated to the discovery and development of medicines to treat diseases that predominantly affect the world’s poor and underserved patient populations. The CWHM consists of a multidisciplinary team of former pharmaceutical company scientists possessing the necessary skill sets required for small molecule drug discovery. The CWHM will consider collaborative proposals to evaluate the effect of tool or candidate compounds on relevant aspects of diarrheal diseases using rat disease models including the castor oil model of diarrhea, the intestinal closed loop model of secretion and the charcoal model of intestinal motility. Partners can provide charactized compounds or our center can conduct the necessary PK, metabolism and stability studies to inform the appropriate conduct of an in vivo disease model study.