Oligo- or poly a (1-2)-D-Glucose-based vaccine for prevention and for treatment of tuberculosis
Oligo- or poly Ci 1~2 -D-glucose-based vaccine for tuberculosis including pneumonia and all primary infections caused by Mycobacterium tuberculosis vaccine, synthetic or natural, that will induce poly a~1~2 -D-glucose antibodies with bactericidal activity against Mycobacterium tuberculosis. These antibodies by be achieved by a: parenteral administration of a vaccine containing a synthetic or a natural saccharide with poly a 1~2 -D-glucose or a structural related antigen. The oligo- or poly a 1~2 -D-glucose; as a natural or synthetic product, may be bound to a carried saccharide and then to a non-toxic non-host protein carrier by directly to a non-toxic non-host protein carrier to form a donjugate. The saccharide-based vaccines is planned for active immunization for prevention of tuberculosis and TIor preparation of immune antibodies as a therapy. The scope of the patent should be confined to this poly Ci 1~2 -D-glucose-based vaccine which is designed to confer specific preventative immunity to infection with Mycobacterium tuberculosis and to induce antibodies specific to poly a 1~2 -D-glucose for therapy of tuberculosis.
Abandoned Patent Reference Number(s): US 60/019,077