Monoclonal Antibodies Which Block Infectivity of Malarial Parasites to Mosquitoes
Monoclonal antibodies (MABs) that block the transmission of malaria (Plasmodium falciparum or Plasmodium gallinaceum) to mosquitoes offer an improved method for controlling the spread of this disease. There has previously been no effective method of preventing mosquitoes for acquiring malarial parasites. These MABs, which block fertilization of the gametes preventing formation of the zygote and development of the zygote in the mosquito midgut, exhibit affinity and specificity for proteins located on the surface of the gametes or ookinetes of the malaria parasite.
Abandoned Patent Reference Number(s): US Patent no: 4,632,909