Screening of Open Global Health Library for Snakebite Drug Discovery
The only effective treatments for snakebite envenoming are antivenoms, medications made from antibodies against the components of venom. However, antivenoms are expensive to manufacture, and different antivenoms are required to treat the bites of different snake species. Prof. Nicholas Casewell at the Liverpool School of Tropical Medicine aims to develop less costly, small-molecule therapies that inhibit toxins in venom. He will screen the Open Global Health Library of Merck KGaA, Darmstadt, Germany to identify compounds that block the activity of such toxic enzymes.