WIPO Fellowship - Identification of functional blocking antibody to inhibit the entry of the malarial parasite in red blood cells

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Completed
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This fellowship of Indra Wibowo from the Institut Teknologi Bandung, Indonesia, with Wai-Hong Tham from the Walter and Eliza Hall Institute of Medical Research (WEHI), Australia, aimed to identify functional blocking antibodies that inhibit red blood cell binding and ligand-receptor interactions present in individuals in a region of high Malaria transmission in Indonesia. PfRh5 is one of the leading vaccine candidates against blood stage P. falciparum and PfRh4 governs the major invasion pathway independent of glycophorin-mediated entry.