WIPO Fellowship - Identification of functional blocking antibody to inhibit the entry of the malarial parasite in red blood cells

Status
Completed
Start date
End date
Disease
Malaria
Research areas
Basic research
Members
Walter and Eliza Hall Institute of Medical Research (WEHI)
Bandung Institute of Technology (ITB)

This fellowship of Indra Wibowo from the Institut Teknologi Bandung, Indonesia, with Wai-Hong Tham from the Walter and Eliza Hall Institute of Medical Research (WEHI), Australia, aimed to identify functional blocking antibodies that inhibit red blood cell binding and ligand-receptor interactions present in individuals in a region of high Malaria transmission in Indonesia. PfRh5 is one of the leading vaccine candidates against blood stage P. falciparum and PfRh4 governs the major invasion pathway independent of glycophorin-mediated entry.