Sharing of MetAP-1 Inhibitor data to inform Tuberculosis drug development strategies
Rates of drug-resistant TB are increasing, and treatments focused on new drug targets are desperately needed. One such potential target is MetAPs, which helps process proteins in Mycobacterium tuberculosis, the bacterium that causes TB. However, GSK’s initial efforts to develop inhibitors of the M. tuberculosis MetAP-1 enzyme were met with disappointing results. GSK shared its data with Dr. Ruminski and colleagues. As a result of this collaboration, CWHM revised its research priorities and placed the TB MetAP-1 inhibitor program on hold, saving an estimated three months of employee time and approximately $50,000 of research costs.