Sharing of MetAP-1 Inhibitor data to inform Tuberculosis drug development strategies

Status
Completed
Start date
End date
Start stage
Screening
End stage
Screening
Disease
Tuberculosis
Research areas
Drug

Rates of drug-resistant TB are increasing, and treatments focused on new drug targets are desperately needed. One such potential target is MetAPs, which helps process proteins in Mycobacterium tuberculosis, the bacterium that causes TB. However, GSK’s initial efforts to develop inhibitors of the M. tuberculosis MetAP-1 enzyme were met with disappointing results. GSK shared its data with Dr. Ruminski and colleagues. As a result of this collaboration, CWHM revised its research priorities and placed the TB MetAP-1 inhibitor program on hold, saving an estimated three months of employee time and approximately $50,000 of research costs.