Repurposing nicotinic Acetylcholine receptor agonists for Hookworm

Status
Completed
Start date
End date
Start stage
Screening
End stage
Screening
Disease
Soil-transmitted helminthiasis (STH)
Research areas
Drug

Dr. Keiser, Head of the Helminth Drug Development Unit at Swiss TPH, maintains in vitro and in vivo assays for a wide range of helminth life cycles. BVGH reviewed a publication detailing the effect of nicotinic acetylcholine receptor (nAChR) agonists on rat hookworm, and contacted Dr. Keiser to gauge her interested in screening related compounds. Dr. Keiser expressed interest, and Pfizer provided seven nAChR agonists that Dr. Keiser screened in her assays against Necator americanus, Ancylostoma ceylanicum, and Heligmosomoides polygyrus.