Repurposing cicotinic Acetylcholine receptor agonists for STH
Soil-transmitted helminthiases, caused by multiple species of parasitic worms, affect more than 1.5 billion people, or nearly 25% of the world’s population. Dr. Keiser, Head of the Helminth Drug Development Unit at Swiss TPH, maintains in vitro and in vivo assays for a wide range of helminth life cycles. As part of its commitment to advancing global public health and accelerating discovery of new treatments for neglected diseases, J&J shared JNJ-46336173, a nicotinic acetylcholine receptor (nAChR) agonist, and over 100 analogs thereof, with Dr. Keiser through WIPO Re:Search. Dr. Keiser screened these compounds for activity against three parasitic helminth species.