Repurposing Avermectins for Buruli Ulcer treatment

Status
Completed
Start date
End date
Start stage
Screening
End stage
Hit ID

Drs. Pluschke and Scherr at the Swiss TPH were interested in repurposing tuberculosis drugs to treat Buruli ulcer, a bacterial infection caused by Mycobacterium ulcerans. BVGH connected Drs. Pluschke and Scherr with Drs. Thompson and Ramon-Garcia at UBC, who had discovered that certain avermectins showed promising activity against M. tuberculosis and other mycobacterial species. The UBC investigators shared eight avermectins with Drs. Pluschke and Scherr, who tested the compounds for their activity in an in vitro screen against clinical isolates of M. ulcerans.