Re-purposing compounds for Chagas disease, Leishmaniasis, Lymphatic Filariasis, and Schistosomiasis drug discovery
Disease
Lymphatic filariasis
Schistosomiasis
Chagas disease
Leishmaniasis
Research areas
Drug
Dr. Siqueira-Neto was interested in screening phosphodiesterase (PDE) V inhibitors for activity against kinetoplastids and schistosomes, as one compound of this class showed activity against a Trypanosoma cruzi PDE involved in osmoregulation. BVGH connected Dr. Siqueira-Neto with Eisai, which provided a select set of PDEV inhibitors for Dr. Siqueira-Neto to screen in cell-based and enzyme-based assays against Trypanosoma, Brugia, Leishmania, and Schistosoma.