Re-purposing compounds for Chagas disease, Leishmaniasis, Lymphatic Filariasis, and Schistosomiasis drug discovery

Status
Completed
Start date
End date
Start stage
Screening
End stage
Screening
Disease
Lymphatic filariasis
Schistosomiasis
Chagas disease
Leishmaniasis
Research areas
Drug

Dr. Siqueira-Neto was interested in screening phosphodiesterase (PDE) V inhibitors for activity against kinetoplastids and schistosomes, as one compound of this class showed activity against a Trypanosoma cruzi PDE involved in osmoregulation. BVGH connected Dr. Siqueira-Neto with Eisai, which provided a select set of PDEV inhibitors for Dr. Siqueira-Neto to screen in cell-based and enzyme-based assays against Trypanosoma, Brugia, Leishmania, and Schistosoma.