Hosting and training in use of PCR to identify antimalarial resistance

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Dr. Chen developed a PCR assay to identify resistance-causing mutations in Plasmodium parasite genes. Dr. Oyibo was interested in identifying specific mutations in Plasmodium parasites known to cause drug resistance in Nigerian patients, information that could potentially inform antimalarial treatment policy. With funding from NIPD, a graduate student from Dr. Oyibo’s laboratory spent two months at NIPD training on the PCR assay with samples collected from malaria patients in Nigeria. Using Dr. Chen’s assay, the student screened the samples for P. falciparum mutations conferring resistance to drugs.