Designing optimized siRNAs for gene silencing in Schistosoma mansoni

Status
Completed
Start date
End date
Start stage
Discovery
End stage
Discovery
Disease
Schistosomiasis
Research areas
Basic research
Drug

Dr. Hoffmann’s laboratory used gene knockdown studies to identify drug targets of clinical importance in S. mansoni, the causative agent of schistosomiasis. Alnylam researchers designed siRNAs for Dr. Hoffmann that were specially optimized for delivery in S. mansoni, and also provided expert guidance on their use.