Data sharing to advance drug development for Kinetoplastid diseases and Malaria
Key Personnel: Michael Pollastri (Northeastern University), Jean-Robert Ioset (DNDi), Byron Arana (DNDi), Marcel Kaiser (Swiss TPH). Dr. Pollastri had identified promising compounds in a screen against Leishmania major (the pathogen that causes cutaneous leishmaniasis). To support drug development efforts against additional neglected diseases, Dr. Pollastri shared his screening data with Drs. Arana and Ioset. With this data, Drs. Arana and Ioset connected with Dr. Kaiser, who screened the compounds for activity against Trypanosoma cruzi, T. brucei, L. donovani, and Plasmodium falciparum. Dr. Kaiser further conducted counter screens to assess cellular cytotoxicity.