Assay Support for Testing Lead Compounds for Activity Against a Specific Mycobacterium tuberculosis Target

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It is estimated that one quarter of the world’s population is infected with tuberculosis (TB). To deter the growing threat of multidrug-resistant tuberculosis, new treatments are needed to successfully reduce the global burden of this disease. Dr. Cynthia Dowd from The George Washington University (GW) has developed lead compounds with anti-tubercular activity, wich could be promising candidates for TB drug development. In order to assist Dr. Dowd in target identification, MSD will be screening these compounds to determine their activity against a specific Mycobacterium tuberculosis target.