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PPT
159 Results for Collaborations
Collaborations
Johnson & Johnson will be sharing a phenotypic screening library with Dr. Lawal Bilbis at UDUS for screening for antimalarial drug discovery. Phenotypic library made up of approximately 1,000 compounds
Leishmania is a parasite that disfigures or kills two million people every year in the developing world. There may be concerns about the efficacy and safety of current antileishmanial agents. In order to address this high-priority gap, Dr. Dawn Wetzel, Assistant Professor of Pediatrics and Pharmacology at UTSW, has identified a specific class of inhibitors with biological activity against Leishmania parasites. In order to support Dr. Wetzel’s antiparasitic screening efforts, Eisai Co., Ltd., has agreed to share inhibitors from this class of compounds.
Key personnel: Dawn Wetzel (UTSW)
Johnson & Johnson will be sharing a highly annotated phenotypic compound library with Dr. Conor Caffrey at the University of California, San Diego to screen for schistosomiasis drug discovery.
173 Results for Assets
Assets
NIH Internal Reference no E-006-1990/0-US-01; US Patent Application no 07/470,692; and E-006-1990/0-US-02; US Patent Application no 08/462,616 Chloroquine an approved drug and the most commonly used antimalarial agent and analogs such as primaquine have been shown to inhibit infectious HIV-1 production and thus its spread in infected individuals. Inhibition may occur via interference with the terminal glycosylation of the viral glycoproteins, which results in the production of noninfectious virus.
This application relates to immunogenic conjugates which elicit an immune response to Plasmodium proteins. This application claims conjugates that include at least one Plasmodium sexual stage surface protein covalently linked to at least one Plasmodium circumsporozoite protein (CSP) or an immunogenic portion of a CSP. Also claimed in the application are conjugates that include at least one sexual stage surface protein covalently linked to at least one immunogenic repeat derived from a Plasmodium CSP. The inventors' data shows that these conjugates also induced long-lasting antibody responses to each of their components, i.e. the vaccine candidates showed both transmission blocking activity and antibodies to the CSP (or portion thereof).
This invention comprises a number of novel anti-mycobacterial compositions, which offer to significantly improve the treatment of mycobacterial infection such as tuberculosis. These newly discovered anti-mycobacterial compounds, which are analogs of thiatetracosanoate, have been shown effective in the treatment of mycobacterial infections and are relatively nontoxic. They may be given alone or in combination with standard anti-mycobacterial drugs and are valuable as antiseptics as well as therapeutics.
DNA segments encoding the Duffy receptor of a Plasmodium parasite A useful protein in the development of a potential malaria vaccine has been developed by cloning the gene for the Duffy binding receptor of Plasmodium vivax, a human malaria. Duffy blood group determinants on human erythrocytes are known to be essential for invasion by both the P. vivax and P. knowlesi malaria strains. A candidate malaria vaccine could result from the use of antibodies to the recombinant Duffy receptor binding protein or the receptor protein itself functioning through competitive blocking therapy.
Pvs28, a vaccine candidate for blocking transmission of plasmodium vivax This invention relates to methods for preventing transmission using PVs28 polypeptide of malaria by eliciting an immune response against parasites responsible for the disease. The Pvs28 polypeptide which is isolated from Plasmodium vivax can be administered to a susceptible organism to prevent transmission of malaria. Claims in this application are drawn to the Pvs28 polypeptide, the nucleic acid molecule which encodes Pvs28, pharmaceutical compositions containing Pvs28, and methods of inducing an immune response against Pvs28.
Oligo- or poly Ci 1~2 -D-glucose-based vaccine for tuberculosis including pneumonia and all primary infections caused by Mycobacterium tuberculosis vaccine, synthetic or natural, that will induce poly a~1~2 -D-glucose antibodies with bactericidal activity against Mycobacterium tuberculosis. These antibodies by be achieved by a: parenteral administration of a vaccine containing a synthetic or a natural saccharide with poly a 1~2 -D-glucose or a structural related antigen. The oligo- or poly a 1~2 -D-glucose; as a natural or synthetic product, may be bound to a carried saccharide and then to a non-toxic non-host protein carrier by directly to a non-toxic non-host protein carrier to form a donjugate. The saccharide-based vaccines is planned for active immunization for prevention of tuberculosis and TIor preparation of immune antibodies as a therapy. The scope of the patent should be confined to this poly Ci 1~2 -D-glucose-based vaccine which is designed to confer specific preventative immunity to infection with Mycobacterium tuberculosis and to induce antibodies specific to poly a 1~2 -D-glucose for therapy of tuberculosis.