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Members
Housed at the Nathan Campus of Griffith University in Brisbane, Australia, the Griffith Institute for Drug...
Founded in 1993, the Infectious Disease Research Institute (IDRI) is focused on developing products that solve...
Surrounded by the delicate ecosystems of the Wet Tropics and the Great Barrier Reef, James Cook University...
Between 2015 and 2016, McGill University and its affiliated hospitals were awarded $473 million in research...
McMaster University is a public research univerity, with its Michael G. DeGroote Institute for Infectious...
The mission of the Massachusetts Institute of Technology (MIT) is to advance knowledge and educate students in...
Collaborations
Dr. Hu developed a dipstick diagnostic for S. japonicum, a species of the parasitic flatworm commonly found in the Far East. BVGH connected Dr. Hu with Dr. Alexander Odaibo at the University of Ibadan, who used samples from Schistosoma-infected patients to assess the dipstick’s ability to detect S. mansoni and S. haematobium, the prevailing species in Africa.
Dr. Demanou, Head of the Arbovirus and Hemorrhagic Fever Virus Laboratory at CPC, believed that dengue fever was underestimated in Cameroon, and was interested in determining the causes and prevalence of non-malarial fevers in the country. BVGH connected Dr. Demanou with Dr. Pinsky, who had developed an RT-PCR diagnostic capable of distinguishing between febrile illnesses. Dr. Demanou provided Dr. Pinsky with over 200 plasma and serum samples from Cameroonian febrile patients, which Dr. Pinsky screened using his multiplexed assay. The results indicated that a large proportion of malaria cases were missed by conventional testing, results that could potentially inform diagnostic development for febrile cases in Cameroon.
Dr. Oyibo was interested in determining which infectious agents (besides malaria) caused febrile illnesses in patients of Lagos state. BVGH connected Dr. Oyibo with Dr. Pinsky, who had developed a highly sensitive real-time RT-PCR-based molecular diagnostic platform that detected and distinguished nucleic acids from dengue virus and Plasmodium parasites. BVGH facilitated the placement of a graduate student from Dr. Oyibo’s laboratory in Dr. Pinsky’s laboratory at Stanford to advance her education and training. Using the multiplex assay to screen Dr. Oyibo’s plasma and whole blood samples from patients with malarial and non-malarial fevers, the student confirmed malaria diagnoses in a significant number of samples that had tested negative by microscopy.
Drs. Pluschke and Scherr at the Swiss TPH were interested in repurposing tuberculosis drugs to treat Buruli ulcer, a bacterial infection caused by Mycobacterium ulcerans. BVGH connected Drs. Pluschke and Scherr with Drs. Thompson and Ramon-Garcia at UBC, who had discovered that certain avermectins showed promising activity against M. tuberculosis and other mycobacterial species. The UBC investigators shared eight avermectins with Drs. Pluschke and Scherr, who tested the compounds for their activity in an in vitro screen against clinical isolates of M. ulcerans.
Drs. Izurieta developed a solar-chemical toilet that sanitizes waste products. To determine the efficacy, he needed to assess the viability of parasite eggs in soil and sewage samples post-sanitization. To assist Dr. Izurieta and his colleague Dr. Reina Ortiz, BVGH connected them with Dr. Selvaganapathy, a biomicrofluidics expert. With support from the USF investigators, Dr. Selvaganapathy developed a tangential flow filtration device and tested the efficacy of the device in concentrating Ascaris eggs.
Dr. Kaushansky was interested in accessing a class of compounds targeting a specific host protein, as she had previously shown that activating this protein might be an effective therapeutic strategy against liver-stage malaria. BVGH connected Dr. Kaushansky with Pfizer, who provided a novel activator compound to support her antimalarial drug discovery efforts.
Assets