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Makerere University has a focused, multi-disciplinary research agenda that includes research projects spanning...
The Association of University Technology Managers (AUTM) is a non-profit organization dedicated to bringing...
The Bibliotheca Alexandrina is a major library and cultural center located in the Egyptian city of Alexandria....
Biotechnology Industry Organization (BIO) is the world's largest trade association representing biotechnology...
The Pasteur Institute is a French non-profit private foundation dedicated to the study of biology, micro...
IRSS is the national health sciences research institute in Burkina Faso.
Investigators at the University of Melbourne and Monash University identified compounds that inhibit the barber’s pole worm, and were interested in screening them against other infectious worms. BVGH connected them with an investigator at University of Buea, who is developing inhibitors against Onchocerca. The University of Buea will screen the University of Melbourne compounds against Onchocerca volvulus to identify potential drug candidates.
Fidelis Cho-Ngwa is the Head of the Pan-African ANDI Centre of Excellence and Associate Professor of Biochemistry and Molecular Biology at the University of Buea in Cameroon. He has a strong interest in onchocerciasis research, given that more than 40% of Camerooonians sufer from that. Fidelis Cho-Ngwa aims at identifying active natural products to be used as drugs against Onchocerca worms. In 2013, he was invited to spend a three-month period at Novartis facilities in Based, Switzerland, where he could acquire in-depth knowledge and skills required to use high-performance liquid chromatography (HPLC) and mass spectrometry (MS) techniques to extract, purify, and identify the active compounds from natural products identified during a tripartite anti-onchocercal phenotypic screen.
Christian Agyare is a professor from the Department of Pharmaceutics of University of Ghana bioactive agents based on medicinal plants for their potential to treat infectious, including NTDs. In October 2013, Christian Agyare was invited to collaborate for a ten-month sabbatical with Conor Caffrey from the Center for Discovery and Innovation in Parasitic Diseases (CDIPD), University of California, San Francisco (UCSF). The purpose of the collaboration was to enhance Christian Agyare's experience in cultivating, maintaining and screening compounds against various parasitic organisms. As a result, he found that at least three hit compounds, fractions and extracts were identified for each parasites and worms.
Gertrude Kyere-Davies is a Master's student at Kwame Nkrumah University of Science and technology (KNUST) of the University of Ghana. She was invited at University of California, San Diego (UCSD), for continuing the research initiated by her professor Christian Agyare in 2013 at University of California, San Francisco (UCSF). The main purpose of her research was to screen various plant extracts and compounds against schistomes and other parasites, such as Trypanosoma cruzi, Leishmania, Trypanosoma brucei, Giardia lamblia and Entamoeba histolytica. The fellowship led to obtain hits that can be further worked on.
Krupa Naran is a postdoctoral fellow at the Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa, collaborating with AstraZeneca on Tuberculosis. In particular, she meant investigating different procedures aimed at assessing the composition of a substance, in order to try to find out which would be the best drug to treat TB.
During her fellowship at the University of Melbourne with the host scientists Leanne Tilley and Matthew Dixon, Tahmina Ahmed from the International Center for Diarrheal Disease Research in Bangladesh (iccdr,b) investigated the antimalarial activity of two novel antimalarial compounds inhibitors. The compounds have been shown to have activity against enzymes that activate ubiquitin and ubiquitin-like proteins. Ms. Ahmed measured the anti-malarial activities of these drugs. This project investigated two drug candidates. Compound 1 proved more potent than chloroquine (IC50 59 nM) and artemisinin (IC50 4 nM). Antimalarial drugs that inhibit apicoplast biogenesis exhibit a delayed death mechanism of killing, however, both compounds 1 and 2 kill parasites rapidly.